What have humans done to deserve dogs? They greet us when we come home, comfort us when we're sad and generally act as loyal companions.
Now, researchers are investigating whether tumors (肿瘤) in dogs may help treat tumors in humans. In early April, the Jackson Laboratory began collecting samples of canine (犬的) tumors. Cells from these tumors inserted into mice could help test new drugs and improve our understanding about how cancer develops and progresses.
Although cancer results from many factors, genes play a critical role. That means the genetic makeup of a tumor can help determine which drugs work against it. So having a broad and diverse pool of genetic makeups increases the chances of finding the right way to attack each disease. This thinking is particularly relevant for rare cancers and rare mutations (突变). Drawing from a larger pool means more genetic mutations to research.
And using tumors from dogs is a nearly ideal way to widen that pool. They're exposed to many of the same environmental factors that might cause cancer in their owners, notes Dr. Christopher Fulkerson. Some bone and brain cancers are far more common in dogs than they are in people, making samples easier to find.
In many cases, the cells in a dog's cancer look and act the same as they would in a human. They can even carry the same genetic mutations. However, not all canine cancers will be particularly helpful for human-focused research. For some types, the similarities between human and dog diseases will be significant. But when they aren't, warns Dr. Jaime Modiano, the differences could have serious consequences for drug development.
But even when the research doesn't advance knowledge of human cancers, it could still help improve the treatment of dogs diagnosed (确诊) with cancer. That's the least we can do for our faithful friends.