The past few months have brought electrifying news that, for the first time, a gene treatment has provided some hearing to children born with deafness.

Eli Lilly announced this week, for example, that a profoundly deaf boy from Morocco given its treatment as part of a clinical trial in Philadelphia can now hear. And five children in China treated similarly at younger ages gained hearing with some able to verbally communicate without their cochlear implants(人工耳蜗). Their hearing recovery, first covered by the press in October 2023, is described in de tail this week in The Lancet.

"It's an enormous achievement," says geneticist Karen Avraham of Tel Aviv University. Otolaryngologist(耳鼻喉科专家) and gene therapist Lawrence Lustig of Columbia University, whose lab was among the first to test the same approach in mice, agrees. "Other than cochlear implants, we haven't really had any successful treatment s to treat deafness," he notes.

The various efforts from companies and academic centers each use a virus to insert the same gene, OTOF, into the children's inner ear so the so-called hair cells there can sense sound and transmit it to the brain.

The new deafness treatments add to a string of recent successes for the gene treatment field, but also raise questions. The ear's hair cells don't divide, so the new copies of OTOF they contain should persist and continue to instruct the cells to make OTOF. Gene expression could drop off over time or the ear could mount an immune response that shuts it off.

But Lustig is optimistic that the various challenges will be overcome. "Now that we've got one success story, there's going to be more money coming in to fund some of these other projects," he says.

George Gershwin, born in 1998, was one of America's greatest composers. He published his first song when he was eighteen years old. During the next twenty years he wrote more than five hundred songs.

Many of Gershwin's songs were first written for musical plays performed in theatres in New York City. These plays were a popular form of entertainment in the 1920s and 1930s. Many of his songs have remained popular as ever. Over the years they have been sung and played in every possible way — from jazz to country.

    In the 1920s there was a debate in the United States about jazz music. Could jazz, some people asked, be considered serious music? In 1924 jazz musician and orchestra leader Paul Whiteman decided to organize a special concert to show that jazz was serious music. Gershwin agreed to compose something for the concert before he realized he had just a few weeks to do it. And in that short time, he composed a piece for piano and orchestra which he called Rhapsody in Blue. Gershwin himself played the piano at the concert. The audience were thrilled when they heard his music. It made him world-famous and showed that jazz music could be both serious and popular.

    In 1928, Gershwin went to Paris. He applied to study composition (作曲)with the well-known musician Nadia Boulanger, but she rejected him. She was afraid that classical study would ruin his jazz-influenced style. While there, Gershwin wrote An American in Paris. When it was first performed, critics (评论家)were divided over the music. Some called it happy and full of life, to others it was silly and boring. But it quickly became popular in Europe and the United States. It still remains one of his most famous works.

    George Gershwin died in 1937, just days after doctors learned he had brain cancer. He was only thirty-nine years old. Newspapers all over the world reported his death on their front pages. People mourned the loss of the man and all the music he might have still written.

The sounds of the Northern Lights have been a mystery to scientists for over a century. But now it seems that a researcher has figured out how auroras (极光) really make sounds. "It has pretty much been confirmed all over the world," "historian Fiona Amery said. "In Canada, Norway and Russia, they are all hearing very much the same sounds." "The auroras can occur hundreds of kilometers above the ground, which strengthens opinions that their sounds are just a false impression," said Fiona. Many scientists argued that auroras were too far away to hear and that any sound would take several minutes to reach the ground, so it was impossible for them to change in time with the auroras.

However, other scientists were convinced that the Northern Lights really made noises. In the 1920s, Canadian astronomer Clarence Chant first suggested a mechanism by which they could occur: The motion of the aurora caused changes in the electrification of the atmosphere that created crackling sounds close to the ground. Almost 100 years later, Clarence's suggestion seems close to what could be the true reason for the sounds.

In 2012，an expert named Unto Laine showed a recording of auroral sounds after years of monitoring auroras. In 2016, he announced the mechanism that makes the sounds: an inversion layer(逆温层) of cold air in the atmosphere that can form below an aurora and a short distance above the ground in calm weather.

Unto argues that visible changes in the aurora cause changes in the inversion layer, causing accumulated electricity to discharge as sparks (火花) that create sounds that can be heard. That explains how the sounds correspond with the aurora 's visible movements 一they begin to happen in the inversion layer only about 75 meters above the observer.