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Persistently engaging in negative thinking patterns may raise the risk of Alzheimer's disease, finds a new UCL-led study. 

In the study of people aged over 55, published in Alzheimer's & Dementia, researchers found 'repetitive negative thinking' (RNT) is linked to subsequent cognitive decline as well as the deposition (沉积) of harmful brain proteins linked to Alzheimer's. 

Lead author Dr Natalie Marchant (UCL Psychiatry) said: "Depression and anxiety in mid-life and old age are already known to be risk factors for dementia(痴呆). Here, we found that certain thinking patterns implicated in depression and anxiety could be an underlying reason why people with those disorders are more likely to develop dementia. 

"We hope that our findings could be used to develop strategies to lower people's risk of dementia by helping them to reduce their negative thinking patterns. "

 For the Alzheimer's Society-supported study, the research team from UCL, INSERM and McGill University studied 292 people over the age of 55 who were part of the PREVENT-AD cohort study, and a further 68 people from the IMAP+ cohort. 

Over a period of two years, the study participants responded to questions about how they typically think about negative experiences, focusing on RNT patterns like rumination (沉思) about the past and worry about the future. The participants also completed measures of depression and anxiety symptoms. 

Their cognitive function was assessed measuring memory, attention, spatial cognition, and language. Some (113) of the participants also underwent PET brain scans, measuring deposits of tau and amyloid, two proteins which cause the most common type of dementia, Alzheimer's disease, when they build up in the brain. 

The researchers found that people who exhibited higher RNT patterns experienced more cognitive decline over a four-year period, and declines in memory (which is among the earlier signs of Alzheimer's disease), and they were more likely to have amyloid and tau deposits in their brain. 

 "We propose that repetitive negative thinking may be a new risk factor for dementia as it could contribute to dementia in a unique way, " said Dr Marchant. 

The researchers suggest that RNT may contribute to Alzheimer's risk via its impact on indicators of stress such as high blood pressure, as other studies have found that physiological stress can contribute to amyloid and tau deposition. 

Co-author Dr Gael Chételat commented: "Our thoughts can have a biological impact on our physical health, which might be positive or negative. Mental training practices such as meditation might help promoting positive- while down-regulating negative-associated mental schemes. 

"Looking after your mental health is important, and it should be a major public health priority, as it's not only important for people's health and well-being in the short term, but it could also impact your eventual risk of dementia. "

(1) Repetitive negative thinking (RNT) is linked to ____.  A. thinking approach improvement in later years B. later cognitive decline and the deposit of harmful brain proteins. C. anxiety disorders which occurs in females solely D. individuals of younger age, which is turning into a trend
(2) According to Dr. Natalie Marchant, certain thinking patterns ____.  A. have no substantial impact on dementia B. are primary contributors to depression and anxiety disorders C. could be a reason why some people are more likely to get dementia. D. Relevant primarily in mid-life, not in old age
(3) In the study over a period of two years, the participants were asked about their ____. A. favorite personal experiences B. daily routines and habits C. typical thinking about negative experiences D. perspectives on various mental health practices
(4) What do the researchers propose as a potential new risk factor for dementia? A. Depression and anxiety disorders B. Accumulation of amyloid and tau deposits in the brain C. Repetitive positive thinking patterns D. Repetitive negative thinking patterns
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I started the latest round of the NtriFit programme weeks ago. We take about 45 minutes to go through participants' health records, previous diets, expectations, and levels of willingness to change to customize(定制)the programme to meet each individual's needs.

I was shocked by one thing. When it comes to weight-loss goals, I usually ask, "When was the last time you were happy with your body?" The reply usually relates to pre-wedding, pre-kids, pre-college-the usual suspects. However this time, almost everyone said, Of course, I wasn't happy with it then, but I'd be happy with it now!"

It made me stop to think. For most of us, no matter how much we don't really like the body shape, there will likely be a point in the future when we would kill for the body we currently have. I don't mean to upset anyone from improving their health right now. But maybe we need to stop and smell the roses. We should be happy and grateful for our bodies exactly as they are.

That's why NutriFit has changed into something much more holistic(整体的). Now we have every shape and size taking part, but the goals are so much bigger: disease prevention, more energy and charity better immunity, ell-balanced hormones. the list goes on. Yes, we get great body part results but you are about so much more than what your body looks like.

In my opinion, the key rule of a successful nutrition programme is to be based on real food. If you focus more on balanced diets and less on weight, it becomes a mentally healthier process. If you're going to maintain your new, healthy lifestyle, it needs to be something you actively enjoy a lifestyle hat you want to maintain. If you eat healthily because you want to rather than you have to, life gets 1,000 percent easier.

(1) What did the author do to customize the programme for individuals? A. Analyze and adjust participants' dietary structure. B. Examine participants' physical health condition. C. Make clear of people's health history and plans. D. Introduce the programme in detail.
(2) What made the author shocked? A. People's discontent with their previous life. B. People's optimism about their current body C. Peoples satisfaction with their former body. D. People's ambitious goals of losing weight,
(3) What does NuriFitpay attention to now? A. People s image. B. People's health C. People's weight D. People's appearance
(4) What should a successful nutrition programme focus on in the author's view? A. A healthy lifestyle. B. A sound exercise plan C. Enough nutritious food D. Weight loss.
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Paris boasts a wealth of world-class museums and architectural masterpieces. From the world's largest art museum to France's most famous landmark, there is plenty to experience in the French capital.

The Louvre Museum

As the most visited art museum in the world and also the largest, the Louvre should be top of your list. It would take you no fewer than 100 days to visit the 35, 000 works of art on display across 300 rooms – and that's if you spend just 30 seconds looking at each one.

The Moulin Rouge (红磨坊)

The Moulin Rouge in Montmartre, with its iconic red windmill, was built in 1885. The venue pioneered the famous French cancan dance, and has now become one of the most famous cabarets in the world. Expect flamboyant handmade costumes of feathers and elegance at every turn.

The Eiffel Tower

Originally built to commemorate the centennial of the French Revolution in 1889, the impressive Eiffel Tower has become the most iconic landmark(地标) of France. The first floor is home to the 58 Tour Eiffel restaurant while the second-floor observation deck provides spectacular bird's eye views – the best in the city.

The top of the Arc de Triomphe

The Arc de Triomphe, a Neoclassical take on the ancient Roman arch, is one of Paris's most iconic attractions. It's worth hiking the 284 stairs to reach the platform on top of the arch as the views span right across the city, towering above the capital at 50m tall.

(1) What can visitors expect to do while visiting Paris? A. Watching the ballet. B. Enjoying the local food. C. Reaching the platform on top of the arch easily. D. Fully understanding the Louvre within one day.
(2) Which is the most graphic placemark of France? A. The Arc De Triomphe. B. The Louvre Museum. C. The Eiffel Tower. D. The Mourin Rouge.
(3) Who is the text most likely intended for? A. Museum-goers. B. Hiking-lovers. C. Dance-lovers. D. Travel-devotees.
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    Can you be too beautiful? It is hardly a problem that most of us have to bother — as much as we might like to dream that it were the case.

    Yet the blessings and curses of beauty have been a long-standing interest in psychology. Do those blessed with shiny faces and an attractive body live in a cloud of appreciation — or does it sometimes pay to be ordinary?

    At the most basic level, beauty might be thought to carry a kind of halo (光环) around it; we see that someone has one good quality, and by association, our deep mind may assume that they have other good ones too.

    Even in the courts, a pleasing appearance can work its magic. Attractive criminals are likely to get less strict sentences, or to escape punishment entirely; attractive plaintiffs (原告), meanwhile, are more likely to win their case and get bigger financial settlements. “It's an effect seen everywhere,” says Walker.

    But if beauty pays in most circumstances, there are still situations where it can have opposite results. While attractive men may be considered better leaders, for instance, hidden sexist prejudices (偏见) can work against attractive women, making them less likely to be hired for high-level jobs that require power. And as you might expect, good-looking people of both sexes run into envy — one study found that if you are interviewed by someone of the same sex, they may be less likely to employ you if they judge that you are more attractive than they are.

    More worryingly, being beautiful or handsome could harm your medical care. We tend to link good looks to health, meaning that illnesses are often taken less seriously when they affect the good-looking. When treating people for pain, for instance, doctors tend to take less care over the more attractive people.

    Ultimately, scientists point out that focusing too much on your appearance can itself be harmful if it creates stress and anxiety — even for those already blessed with good looks. “If you are crazy about attractiveness, it may affect your experience and interactions,” she says. It's an outdated saying, but no amount of beauty can make up for a bad personality. As the writer Dorothy Parker put it so elegantly: “Beauty is only skin deep, but ugly goes clean to the bone.”

(1) From paragraph 1, we can learn that _______. A. some may be bothered by their unattractive appearance B. most people are not afraid of being too beautiful C. we might always dream about being bothered by others D. being too beautiful can be a problem bothering everyone
(2) Which is the benefit for beautiful people? A. All attractive plaintiffs have more chances to get away with punishment. B. Women with pleasing appearance will always be considered as better leaders. C. Good-looking people are often regarded as having many good qualities. D. Beautiful criminals are more likely to persuade the judge and win the case.
(3) The writer mentioned the underlined sentence in the last paragraph to _______. A. persuade us to pay more attention to our looks from now on B. suggest that beauty can help make a better personality C. encourage us to focus more on improving our personality D. ask ugly people to have more confidence in their personality
(4) What might be the best title for the passage? A. Beauty, a blessing? B. Sexist Prejudice. C. Real beauty. D. Benefits Beauty holds.
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