1.阅读理解

In a study published in Nature Machine Intelligence, researchers at Ohio State University show how artificial intelligence (AI) can follow clinical trials to identify drugs for repurposing, a solution that can help advance innovative treatments.

Repurposing drugs is legal and not unusual. When doctors prescribe drugs that have been approved by the Food and Drug Administration (FDA) for purposes different from what is printed on the labels, the drugs are being used "off - label". Just because a drug is FDA - approved for a specific type of disease does not prevent it from having possible benefits for other purposes.

For example, Metformin, a drug that is FDA - approved for treating type 2 diabetes, is also used to treat PCOS (a disease of women), and other diseases. Trazodone, an anti - depressant with FDA - approval to treat depression, is also prescribed by doctors to help treat patients with sleep issues.

The Ohio State University research team created an AI deep learning model for predicting treatment probability with patient data including the treatment, outcomes , and potential confounders (干扰因素).

Confounders are related to the exposure and outcome. For example , a connection is identified between music festivals and increases in skin rashes (红疹). Music festivals do not directly cause skin rashes. In this case, one possible confounding factor between the two may be outdoor heat, as music festivals tend to run outdoors when the temperature is high, and heat is a known cause for rashes. When working with real - world data, confounders could number in the thousands. AI deep learning is well-suited to find patterns in the complexity of potentially thousands of confounders.

The researcher team used confounders including population data and co-prescribed drugs. With this proof -of-concept, now clinicians have a powerful AI tool to rapidly discover new treatments by repurposing existing medications.

(1) What do we know about a drug used off-label? A. It is sold without a label. B. It is available at a low price. C. Its uses extend beyond the original. D. Its clinical trials are rejected by doctors.
(2) What do Metformin and Trazodone have in common? A. They are used off-label. B. They treat rare diseases. C. They result in sleep issues. D. They are medical breakthroughs.
(3) What can be inferred about "confounders"? A. They are possible treatments. B. They are environmental factors. C. They can be easily recognized in data. D. They should be taken into consideration.
(4) What is the main idea of the text? A. AI examines benefits of existing drugs. B. AI identifies off-label uses for drugs. C. AI proves the power of drug research. D. AI finds new drugs for common diseases.
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主旨大意; 推理判断题; 细节理解题; 科普环保类; 说明文;
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1.阅读理解

Body mass index (BMI) has long been foundational in healthcare around the world. The simple equation(方程) of weight relative to height has been used to determine your risk for certain diseases. But researchers have been questioning the value of BMI in individual health assessment now.

BMI was never intended to measure individual health. It was developed in the early 1800s to study weight variations across entire population. BMI is a rigid number based on old data," says Fatima Stanford, a professor at Harvard Medical School. And it's far from perfect in terms of the cutoffs(分界点) designed to indicate risk, she added.

A study estimated that more than 74 million American adults were miscategorized(被误分类) as unhealthy or healthy based on their BMI alone. Nearly half of people considered over weight and 29percent categorized as obese were actually healthy. Thirty percent of those considered to be at a normal weight had heart issues.

Part of the problem is that BMI doesn't tell the difference between weight from fat and muscle. So bodybuilders and athletes with high muscle mass may be categorized as overweight or obese. And even among people who do have higher body fat, BMI doesn't tell physicians anything about how the fat is distributed—a key connection to disease risk.

Furthermore, BMI cutoffs are largely based on data from western populations, making it a problem to apply this measurement to the diverse American population. There's growing evidence that body composition varies from race to race. African Americans, for example, are likely to carry more fat around the hips than white Americans. A study showed that for black adults in the U. S. , having a higher BMI (25and over) did not carry the same risk of death as it did in white adults.

Regardless of the BMI category you fall into, it's important to find a healthcare provider who will look beyond that number to get a whole picture of your health. Because despite the view that people with a higher BMI have a greater risk for a number of diseases than thinner people, the research shows it's not that simple.

(1) What do we know about BMI? A. It acts a decisive part in healthcare. B. It does well indicating health risks. C. It's intended to measure individual health. D. It shows the relation between weight and height.
(2) Why may some bodybuilders and athletes be miscategorized as overweight? A. They provided wrong data. B. BMI took their muscle for fat. C. BMI failed to indicate fat distribution. D. No other measurements were used than BMI.
(3) Which of the following is right according to Paragraph 5? A. BMI cutoff of African Americans is 25. B. BMI is accurate for people from different races. C. BMI cutoffs can't apply to all the people in the U. S. D. White adults are less likely to carry the risk of death than black adults.
(4) What is the author's attitude towards BMI? A. Cautious. B. Dependent. C. Convinced. D. Disapproving.
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2.阅读下列短文, 从每题所给的A、B、C、D四个选项中选出最佳选项。

Whilethe benefits of Zoom and other videoconferencing tools made them absolutelyessential in the pandemic(疫情), the researchsuggests that heavy reliance on the technology comes at a cost to creativethinking.

Brucksat Columbia University and her team started their investigation when managersreported having trouble innovating with remote workers. Brucks doubted whethervideoconferencing was a factor, suspecting that difficulties coordinating(协调) large, global teams online might be to blame instead.

Tofind out, the researchers analysed ideas for new products generated by 1, 490engineers for a multinational company. The engineers, who were in Finland,Hungary, India, Israel and Portugal, were randomly paired up and given an houror so to brainstorm products either in person or over videoconferencing. Theythen selected their best idea.

Writingin Nature, the researchers reportthat the engineers produced more ideas, and more innovative ideas, when workingface to face. "They are not only generating a larger number of creativeideas, but their best idea is better, " Brucks said. Virtual teams werejust as good at selecting the best ideas from a bunch as those that met inperson.

"Visualfocus is a huge component of cognitive(认知) focus. When you'refocused on the screen and ignoring the rest of the environment, that affectshow you approach the task, " said Brucks. "It's uniquely bad forcreativity because it's inhibiting broader exploration."

Bruckssaid the impact on the real world "could be huge", leading to adivision of labour between face­to­face and virtual meetings that could "permanentlyreshape the office and work schedules". But she urged businesses to becautious, because if virtual meetings are cheaper than in­person ones, they maystill be more cost­effective.

Askedfor tips, Brucks said people could save more creative tasks for in­personmeetings, or turn off their camera when coming up with ideas. "I think itunlocks more creative thinking, " she said.

(1) Why did Brucks conduct the research? A. To prove her assumption. B. To clarify a new concept. C. To make a comparison. D. To explain a rule.
(2) What is the finding of the research? A. Face­to­face gatherings promote cross­culture ties. B. Workers think less creatively in virtual meetings. C. Individual work generates more innovative ideas. D. Videoconferencing has an irreplaceable role.
(3) What does the underlined word "inhibiting" in paragraph 5 mean? A. Encouraging. B. Requiring. C. Beginning. D. Preventing.
(4) What does Brucks say about virtual meetings? A. They should be used accordingly. B. They'll make office workers divided. C. They'll give way to in­person meetings. D. They help businesses run more efficiently.
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3.阅读理解

Plenty of audiences have warned: don't see the new French movie The Taste of Things on an empty stomach. Juliette Binoche plays a longtime personal cook to a man who's a gourmand(美食家). They share a passion for food. Filled with delicious meals, the film celebrates food, and all the work and love that go into making it.

When you see a delicious meal in a movie or an ad, chances are that it's not fit to eat. Food stylists have been known to substitute glue for milk, and coat meat with motor oil. All this was a big "No" for Vietnamese French director Tran Anh Hung.

Tran says he wanted everything in The Taste of Things "to be real," from the raw ingredients(食材)to the menu to the way the cooks move in the kitchen. Real food can't always handle multiple takes. Plus, Tran needed to show dishes at different stages of preparation. So he needed a lot of everything. For a classic French dish, "we needed 40 kilos of meat for the shooting." He also had to find vegetables that looked like they were harvested in the 19th century. "They're not as beautiful as today," he says, "They're not straight, and they have many spots on the skin."

After doing extensive research into the history of French cuisine and working with a historian, Tran enlisted three-star chef Pierre Gagnaire to make sure the menu he'd come up with worked in real life.

Gagnaire also cooked for Tran for five days, so the director could study his movements in preparation for filming. Tran says watching Gagnaire move around the kitchen taught him that "simplicity is important and you don't need to have the perfect gesture for this or that. You need only to be very free." Gagnaire says the movie feels like a gift. "For my creativity, it's an honor," he says. The famous chef agreed to take a small part in the film.

"When you leave this film, you feel calm because instead of violence, there's tenderness," Gagnaire says.

(1)  What can we say about The Taste of Things? A. It shows that food represents love. B. It gives audience a good appetite. C. Its characters only focus on cooking. D. Its story is based on a food stylist.
(2)  Which of the following best describes Tran as a film director? A. Romantic. B. Caring. C. Demanding. D. Humorous.
(3)  Why did Gagnaire cook for Tran for five days? A. To get a role in Tran's movie. B. To give Tran some inspiration. C. To test Tran's menu for the film. D. To show Tran his food creativity.
(4) What's the author's purpose in writing the text? A. To show a film shooting style. B. To recommend a film. C. To call on people to save food. D. To promote food culture.
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